Elucidating mechanism cellular uptake removal protein who is melissa harris lacewell dating
These findings significantly advance our general understanding of exosome-mediated uptake and offer potential strategies for how this pathway may be targeted through modulation of CAV1 expression and ERK1/2 signaling.
The process of endocytosis involves multiple mechanisms in mammalian cells differing in the type of cargo and fate of cargo upon internalization.
Interestingly, exosome uptake appears dependent on unperturbed ERK1/2-HSP27 signaling, and ERK1/2 phosphorylation is under negative influence by CAV1 during internalization of exosomes.Thiamine is soluble in water, methanol, and glycerol and practically insoluble in less polar organic solvents.It is stable at acidic p H, but is unstable in alkaline solutions.We now report that internalization of exosomes derived from glioblastoma (GBM) cells involves nonclassical, lipid raft-dependent endocytosis.Importantly, we show that the lipid raft-associated protein caveolin-1 (CAV1), in analogy with its previously described role in virus uptake, negatively regulates the uptake of exosomes.
Conclusion: Our findings provide novel insights into cellular uptake of exosomes.